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. Author manuscript; available in PMC: 2011 Jul 28.
Published in final edited form as: Int Rev Neurobiol. 2009;88:65–100. doi: 10.1016/S0074-7742(09)88004-5

Fig. 8.

Fig. 8

Nissl-stained sections from the cerebral cortex (left panel) and choroid plexus (right panel) from control (a, b), METH-23°C (c, d) and METH-29°C (e, f) treated rats. Most of the nerve cells in the control cortex are healthy with a distinct nucleus in the center. Only a few nerve cells show condense cytoplasm (arrowheads, a). On the other hand, dark and distorted neurons were frequent in METH-treated rats (c and e; arrows). Sponginess (*) and perivascular edema (arrowheads; c, e) are frequent in METH-treated rats; the changes are more pronounced at 29° C (e) compared to 23° C (c). Bars (a, c, e) = 50 µm. Nissl-stained choroid epithelial cells in control (b) show compact and densely packer epithelial cells with distinct cell nucleus (arrow, b). METH treatment at 23° C resulted in mild degeneration of choroid epithelium (arrows, d). The epithelial cell nucleus also appears to be disintegrated (d). These degenerating changes in the choroidal epithelium is most pronounced in the rat that received METH at 29° C (arrows, f). Bars (b = 50 µm; d = 40 µm, f = 60 µm).