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. Author manuscript; available in PMC: 2012 Apr 8.
Published in final edited form as: Mol Cell. 2011 Apr 8;42(1):36–49. doi: 10.1016/j.molcel.2011.02.020

Figure 7. Rapamycin reactivates senescence in PDAC harboring activated PIK3CA/AKT.

Figure 7

(a) Immunohistochemical staining of AKT pathway activation in pancreata of RASG12D/PTENfl/fl mice or RASG12D mice. (b) RASG12D/PTENfl/+ mice were treated with rapamycin for 7 days and then pancreata harvested and stained for p53, p21 and BrdU. Box plots as Figure 4e.