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. Author manuscript; available in PMC: 2011 Jul 28.
Published in final edited form as: Expert Rev Endocrinol Metab. 2011 Jul 1;6(4):557–561. doi: 10.1586/eem.11.42

Figure 1.

Figure 1

illustrates the pathophysiology of type 2 diabetes in the setting of obesity. Chronic caloric surplus and physical inactivity leads to obesity and insulin resistance. Beta cell failure is required in this setting to drive the transition from obesity/insulin resistance to type 2 diabetes. Both Roux-en-Y gastric bypass (RYGB) surgery and diet/exercise contribute to beta cell recovery thru weight loss, restoration of incretin function and improvement of insulin sensitivity. Evidently, the magnitude of these effects is far greater following bariatric surgery than diet/exercise interventions represented by the + symbol.