Table 2.

Association of estimated glomerular filtration rate with cognitive decline and brain atrophy in individuals with and without Alzheimer disease

	Cognitive decline							Brain atrophy
	AD n = 44			Non-AD n = 56			eGFR × group interactiona	AD n = 34			Non-AD n = 47			eGFR × group interactiona
Equation	β	R2Δ	P-value	β	R2Δ	P-value	P-value	β	R2Δ	P-value	β	R2Δ	P-value	P-value
MDRD	− 0.31	0.081	0.04	0.18	0.028	0.22	0.006	− 0.44	0.155	0.02	0.27	0.067	0.08	0.001
CG	− 0.21	0.020	0.31	− 0.06	0.020	0.77	0.02	− 0.40	0.067	0.15	0.35	0.072	0.07	0.005
Macdonald	− 0.16	0.020	0.31	− 0.01	0.000	0.96	0.58	− 0.23	0.037	0.28	0.18	0.025	0.28	0.10
Taylor	− 0.22	0.026	0.25	0.18	0.014	0.39	0.97	− 0.27	0.036	0.29	− 0.01	0.000	0.97	0.55

^aInteraction term represents the group (AD or non-AD) by eGFR interaction for the respective equations in predicting the cognitive decline and brain atrophy.

β-values represent the direction of correlation between eGFR with cognitive decline and brain atrophy.

eGFR, estimated glomerular filtration rate; AD, Alzheimer dementia; Δ, change; MDRD, Modification of Diet in Renal Disease; CG, Cockroft–Gault.