TABLE 1.

Overview of Key Examples of Toxicogenomics Applications

Clustering of compounds in similar mechanistic classes

Generation of hypotheses regarding compound action

Revelation of mechanisms of compound action

Classification of blinded compounds

Clustering of compounds by elicited toxicant phenotype

Ranking and categorization of drug candidates by toxicogenomics signature

Discerning no effect level for compound transcript effect

Discovery of biomarkers of toxicity

Discovery of exposure biomarkers

Validation/qualification of biomarker signatures