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Renal histopathology and function. (a) PAS staining of glomeruli. ×400; (b) glomerular volume in each group. Urine volume (c), albuminuria (d) and creatinine clearance (CCR) (e). ZL, normal lean rat; ZF, ZDF rat; ZF + AG, ZDF rat treated with AG (50 mg/kg); ZF + KIOM-79, ZDF rat treated with KIOM-79 (50 mg/kg). All data were expressed as mean ± SD (n = 6-7). ***P < .001 versus ZL; ## P < .01; # P < .05 versus ZF group, respectively.
