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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Jul;70(7):596–609. doi: 10.1097/NEN.0b013e31822146ca

Figure 2.

Figure 2

Immunohistochemical expression profiles of p21CIP1/WAF1and p16INK4A and p14ARF in atypical teratoid/rhabdoid (AT/RT) and non-CNS malignant rhabdoid tumors (MRT). (A, B) Representative images displaying lack of expression (score = 0) of both p21CIP1/WAF1 (A) and p16INK4A (B) in AT/RT cases. (C) Representative image from an AT/RT case showing strong (3+) p14ARF expression. (D) Semiquantitative estimation of staining in all AT/RT and non-CNS MRT cases. p14ARF expression ranged from focal weak to diffuse strong staining and was higher in both AT/RT and non-CNS MRT relative to p21CIP1/WAF1and p16INK4A expression. Data were analyzed using ANOVA (***p < 0.0001). The y-axis represents a semiquantitative measure of the product of staining intensity and percentage of positive cells in each case.