Table 1.
Patient Characteristics and TP53 Mutational Analysis
| Atypical Teratoid / Rhabdoid Tumor | ||||
|---|---|---|---|---|
| Case No. | Age (mo) | Sex | Location | TP53 polymorphism/ mutation |
| 1 | 11 | F | Cerebello-pontine angle | Yes |
| 2 | 17 | M | Brain and spinal cord | Yes |
| 3 | 47 | M | Cerebellum | Not assessed |
| 4 | 6 | M | Pineal region | Not assessed |
| 5 | 9 | F | Pineal region | Not assessed |
| 6 | 19 | M | Pineal region | Yes |
| 7 | 53 | M | Temporal lobe | Yes, c.722C>T (Ser>Phe) |
| 8 | 21 | F | Cerebellum | Yes |
| 9 | 21 | M | Cerebellum | Yes |
| 10 | 23 | F | Cervical Spinal Cord | Yes |
| 11 | 96 | M | Clivus | Not assessed |
| 12 | 96 | M | Clivus | Yes |
| 13 | 19 | M | Cerebellum | Yes |
| 14 | 26 | M | Brain, not specified | Yes |
| 15 | 30 | M | Brain, not specified | Yes, c.246G>A (Pro>Pro) |
| 16 | 52 | F | Cerebellum | Yes |
| 17 | 120 | M | Spine | Yes |
| 18 | 9 | F | Brain, not specified | Yes, c.467G>A (Arg>His), c.582T>C (Leu>Leu) |
| 19 | 11 | M | Cerebellum | Not assessed |
| 20 | 11 | M | Cerebello-pontine angle | Yes |
| 21 | 44 | M | Frontal lobe | Not assessed |
| 22 | 44 | M | Frontal lobe | Yes |
| 23 | 17 | M | Cerebello-pontine angle | Yes |
| 24 | 13 | M | 4th Ventricle | Yes |
| 25 | 6 | F | Cerebellum | Yes |
| Non-CNS Malignant Rhabdoid Tumor | ||||
|---|---|---|---|---|
| Case No. | Age mo. | Sex | Location | TP53 polymorphism/ mutation |
| 1 | 6 | F | Neck | Yes |
| 2 | 96 | F | Neck | Yes |
| 3 | 108 | M | Cervical Lymph Node | Yes |
| 4 | 52 | F | Hand | Yes |
| 5 | 96 | M | Liver | Yes |
| 6 | 240 | M | Abdomen | Not assessed |
| 7 | 96 | M | Axilla | Not assessed |
| 8 | 32 | F | Liver | Yes |
| 9 | 56 | F | Face | Not assessed |
| 10 | 40 | F | Liver | Yes |
| 11 | 6 | F | Kidney | Yes |
The tissue microarray contained 25 cases of atypical teratoird/rhabdoid tumor (AT/RT) and 11 cases of non-CNS malignant rhabdoid tumor (MRT). F = Female; M = Male; c. = codon; C = cytosine; T = thymidine; G = guanine; A = arginine= Ser = serine; Phe = phenylalanine; Pro = proline; Arg = arginine, His – histidine, Leu – Leucine.