Table 3.
Effect on liver and kidney function tests during oral toxicity studies of active principle (LH II) isolated from ethanolic extract of seeds in normal rabbits (1 month treatment).
| Parameter | Healthy control | Treated 5 times of effective dose | Treated 10 times of effective dose | Treated 15 times of effective dose |
|---|---|---|---|---|
| Serum Bilirubin (mg dL−1) | 0.45 ± 0.02 | 0.44 ± 0.03 | 0.44 ± 0.02 | 0.44 ± 0.02 |
| SGPT (IU L−1) | 11.2 ± 1.1 | 12.1 ± 1.3 | 11.5 ± 0.9 | 11.5 ± 0.9 |
| Serum ALP (U L−1) | 33.0 ± 2.4 | 33.2 ± 3.1 | 33.0 ± 2.8 | 33.0 ± 2.8 |
| Serum protein (g dL−1) | 8.0 ± 0.9 | 7.9 ± 0.6 | 8.0 ± 0.6 | 8.0 ± 0.2 |
| Blood urea (mg dL−1) | 15.0 ± 1.3 | 15.0 ± 1.7 | 15.9 ± 1.5 | 15.4 ± 1.8 |
| Serum Creatinine (mg dL−1) | 1.3 ± 0.1 | 1.4 ± 0.3 | 1.4 ± 0.1 | 1.4 ± 0.2 |
Values are mean ± SEM for five animals in each group. No significant difference between control and treated groups.