Table 4.
Nonhematologic toxicities occurring in >10% of patients
| Toxicity Type | Maximum Toxicity Grade |
|||||||
|---|---|---|---|---|---|---|---|---|
| Course 1 (24 patient-courses)a |
Courses 2–12 (160 patient-courses) |
|||||||
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Fatigue | 3 | 4 | 1 | |||||
| Anorexia | 1 | 2 | 2 | 1 | ||||
| Constipation | 2 | 1 | 5 | |||||
| Diarrhea | 4 | 3 | 3 | |||||
| Nausea | 4 | 1 | 8 | 1 | ||||
| Vomiting | 5 | 4 | 1 | 3 | 6 | 2 | ||
| ALT, SGPT | 4 | 7 | ||||||
| AST, SGOT | 4 | 6 | ||||||
| Pain, stomach | 3 | 1 | ||||||
ALT, alanine aminotransferase; AST, aspartate aminotransferase; SGPT, serum glutamic pyruvic transaminase; SGOT, serum glutamic oxalacetic transaminase. a23 patient-courses were deemed evaluable for nonhematologic toxicities.