Skip to main content
. Author manuscript; available in PMC: 2011 Jul 28.
Published in final edited form as: Chemistry. 2010 Sep 24;16(36):10959–10962. doi: 10.1002/chem.201001651

Table 1.

Click–cyclize protocol to diverse benzothiaoxazepine-1,1-dioxides.

graphic file with name nihms308760u1.jpg
Entry R1 R2 R3 Sulfonamide (yield [%])[a] Sultam (yield [%]) [a]
1 4-Br Ph H 3a (93) 4a (89)
2 4-Br iPr H 3b (96) 4b (87)
3 4-Br iBu H 3c (97) 4c (94)
4 4-Br Bn H 3d (89) 4d (83)
5 4-Br Me Ph 3e (92) 4e (95)
6 6-F iBu H 3 f (93) 4 f (88)
7 6-F Me Ph 3g (94) 4g (92)
8 4-F iBu H 3h (95) 4h (93)
[a]

Yields of isolated product after column chromatography.