Table 3.

Adjusted odds ratios (ORs) for adenomas and hyperplastic polyps in relation to red meat consumption and preparation, cigarette smoking, and mEH polymorphisms split by anatomic location.

		Adenomas						Hyperplastic Polyps
	Controls	Proximal (N=187)			Distal/Rectal (N=256)			Proximal (N=235)			Distal/Rectal (N=339)
	N	N	OR	95% CI	N	OR	95% CI	N	OR	95% CI	N	OR	95% CI
Servings red meat/wka
0 (ref)	101	21	1.00		24	1.00		31	1.00		26	1.00
1–3	415	101	1.10	0.65–1.88	142	1.58	0.95–2.63	128	1.01	0.64–1.59	189	2.07	1.26–3.42
>3	224	63	1.10	0.62–1.94	120	1.49	0.87–2.56	73	1.01	0.61–1.66	120	2.03	1.20–3.44
p-trend			0.82			0.32			0.97			0.05
Red meat prepa
No red meat (ref)	101	21	1.00		24	1.00		31	1.00		26	1.00
Lightly browned	89	26	1.27	0.66–2.45	29	1.37	0.72–2.59	32	1.15	0.64–2.06	41	1.86	1.01–3.42
Medium browned	400	90	0.99	0.58–1.66	143	1.59	0.96–2.66	124	1.02	0.64–1.62	187	2.10	1.27–3.47
Heavily browned/	169	48	1.28	0.71–2.30	59	1.55	0.89–2.73	45	0.90	0.53–1.53	81	2.08	1.21–3.59
Blackened
p-trend			0.61			0.11			0.58			0.01
Smoking pack-yrsa
0 (ref)	459	104	1.00			1.00		154	1.00		145	1.00
0.01–21.99	225	75	1.11	0.76–1.61	39	1.06	0.75–1.48	62	0.88	0.62–1.24	113	1.66	1.22–2.26
≥22	81	8	1.23	0.72–2.12	70	2.02	1.30–3.14	18	0.86	0.49–1.52	78	3.70	2.49–5.50
p-trend			0.41		45	0.01			0.44			<0.01
Smoking statusa
Never (ref)	459	68	1.00		139	1.00		154	1.00		145	1.00
Former	280	55	1.14	0.81–1.61	101	1.23	0.93–1.64	72	0.87	0.63–1.21	154	1.87	1.40–2.50
Current	32	16	1.22	0.53–2.80	16	1.77	0.92–3.42	9	0.87	0.38–1.99	40	4.21	2.47–7.15
p-trend			0.43			0.06			0.42			<0.01
mEH Exon 3a
Tyr/Tyr (Fast) (ref)	281	90	1.00		102	1.00		93	1.00		110	1.00
His/Tyr (Medium)	252	42	0.89	0.60–1.32	88	0.95	0.68–1.32	70	0.84	0.59–1.32	114	1.15	0.84–1.58
His/His (Slow)	56	7	1.16	0.63–2.16	13	0.62	0.32–1.18	18	1.01	0.63–2.16	29	1.33	0.81–2.20
p-trend			0.62			0.23			0.95			0.21
mEH Exon 4a
His/His (Slow) (ref)	379	54	1.00		123	1.00		117	1.00		157	1.00
Arg/His (Medium)	193	57	0.92	0.61–1.38	70	1.12	0.79–1.57	53	0.88	0.61–1.27	89	1.12	0.82–1.53
Arg/Arg (Fast)	17	28	1.67	0.67–4.16	5	1.97	0.87–4.45	11	2.23	1.01–4.93	7	1.06	0.43–2.61
p-trend			0.30			0.17			0.65			0.63
Predicted mEH activitya,b
Slow (ref)	224	54	1.00		68	1.00		63	1.00		101	1.00
Medium	247	57	0.97	0.64–1.47	87	1.18	0.82–1.71	79	1.13	0.78–1.66	105	0.94	0.67–1.31
Fast	118	28	0.99	0.59–1.64	48	1.38	0.89–2.13	39	1.16	0.74–1.84	47	0.90	0.59–1.36
p-trend			0.93			0.15			0.71			0.60

^aAdjusted for age, gender, race, education, BMI, alcohol intake, NSAIDs use, and hormone therapy use. Additionally, meat analyses

^bAdjusted for age, sex, race (N=1677)

^cPredicted mEH activity is based on the classification by Benhamou, et el. (36)