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CSR pathways for primary non-HCC hepatocytes and HCC (Huh7) cell types. (a) Generic pathway comprised of canonical edges extracted from literature (b) non-canonical edges for Huh7 and primary hepatocytes extracted from a data-driven approach (multi linear regression) (c) extended pathways for Huh7 and primary hepatocytes constructed by fitting canonical and non-canonical edges to experimental data via an ILP formulation.
