Table 2.
Time response in JF1 and C3 mice after single instillation of 20 μg Printex 90: BAL cell differentials and protein markers expressed in lung tissue at day 1 and day 7
| JF1/Msf | C3H/HeJ | ||||
|---|---|---|---|---|---|
| Day1 | Day7 | Day1 | Day7 | ||
| BAL cell differentials | PMN | ↑ | ↑ | ↑ | ↑ ↔ |
| Macrophages | NR | ↑ | NR | NR | |
| Lymphocytes | NR | ↑ | NR | NR | |
| Lung tissue proteins | IL1B | ↑ | ↑ | ↑ | ↑ |
| TNF | ↑ | ↑ | ↑ | ↔ | |
| IL4 | ↔ | ↑ | ↑ | ↔ | |
| CCL22 | ↑ | ↑ | ↑ | ↔ | |
| F7 | ↑ | ↑ | ↑ | ↔ | |
| vWF | ↑ | ↑ | ↑ | ↑ | |
| IL18 | ↓ | ↓ | ↑ | ↑ | |
| VEGF | NR | NR | ↑ | ↑ | |
| CSF1 | ↑ | ↔ | ↑ | ↑ | |
| CCL11 | ↑ | ↔ | ↑ | ↑ | |
| CCL5 | NR | NR | ↑ | ↑ | |
| CCL9 | ↑ | ↔ | ↑ | ↑ | |
| CD40L | NR | NR | ↑ | ↑ | |
| CCL4 | ↑ | ↔ | ↑ | ↑ | |
| XCL1 | NR | NR | ↑ | ↑ | |
| CXCL5 | ↑ | ↑ ↔ | ↑ | ↑ | |
| CCL3 | NR | NR | ↑ | ↑ | |
| F3 | NR | NR | ↑ | ↑ ↔ | |
| FGF2 | NR | NR | ↑ | ↑ | |
| EDN1 | NR | NR | ↑ | ↑ | |
| APCS | NR | NR | ↑ | ↑ | |
| FGA | ↑ | ↔ | ↑ | ↑ | |
| THPO | ↑ | ↑ ↔ | ↑ | ↑ | |
↑: Higher than control; ↓: Lower than control; ↔: Equivalent to control; ↑↔: higher than control but lower than day 1; NR: no response; (C3H/HeJ data from reference 21)