Table 1.

Characteristics of 226 Patients Receiving Fluoroquinolone (FQ) Antibiotics

Characteristic	Unnecessary (n = 70)	Necessary (n = 157)	P Value
Age in years-median (IQR)	65 (49, 80)	59 (45, 72)	0.045
Males	30 (43)	70 (45)	0.81
Hospitalized in previous 12 months	48 (69)	101 (64)	0.58
Antibiotics in previous 3 months	29 (41)	83 (53)	0.11
FQ antibiotics in previous 3 months	11 (16)	33 (21)	0.35
Long-term care resident	20 (29)	36 (23)	0.38
Comorbidities
Diabetes	23 (33)	53 (34)	0.89
Cancer	9 (13)	30 (19)	0.25
Chronic neurological condition	17 (24)	28 (18)	0.26
Dementia	12 (17)	16 (10)	0.14
Service First Prescribing FQs
Emergency Department	22 (31)	55 (35)	0.60
Medicine	25 (36)	68 (43)	0.28
Surgery	6 (9)	21 (13)	0.38
Family Practice	8 (11)	6 (4)	0.04
Rehabilitation Medicine	9 (13)	3 (2)	0.002
Obstetrics/Gynecology	0 (0)	4 (3)	0.31
Indication
Treatment	68 (97)	150 (96)	0.73
Prophylaxis	2 (3)	7 (4)
Regimen
FQ as monotherapy	46 (66)	51 (32)	< 0.001
FQ in combination with other antimicrobials	24 (34)	106 (68)
Syndrome
Urinary	36 (51)	28 (18)	< 0.001
Pulmonary	2 (3)	50 (32)	< 0.001
Upper respiratory tract	4 (6)	9 (6)	1.000
Bacteremia	3 (4)	7 (4)	1.000
Fever or sepsis syndrome	3 (4)	11 (7)	0.56
Diarrhea	2 (3)	3 (2)	0.65
Intra-abdominal	2 (3)	20 (13)	0.03
Skin and soft tissue	4 (6)	7 (5)	0.74
Non-infectious condition	11 (16)	18 (11)	0.39
Other	3 (4)	4 (3)	0.68

Interquartile range (IQR). Data are number of regimens (percentage of regimen category) unless otherwise indicated. Categorical data were assessed using Pearson Chi-square test or Fisher's exact test; Fisher's exact test was used for categorical data when the expected value for any given cell was less than 10.