Table 2.
A summary of gene expression changes induced by BaP in MCF7 cells using microarray and RT-PCR analysis
| Change in G1 | Change in S | Change in G2/M | |||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Biological function | RT-PCR | Microarrays | RT-PCR | Microarrays | RT-PCR | Microarrays |
| CYP1A1 | Xenobiotic metabolism | ↑ 91.5-fold | ─ | ↑ 1866.8-fold | ─ | ↑ 73.7-fold | ─ |
| CYP1B1 | Xenobiotic metabolism | ↑ 19-fold | ↑ 2.7-fold | ↑ 40.4-fold | ↑ 3.2-fold | ↑ 21.9-fold | ↑ 2.3-fold |
| GDF15 | Cell differentiation | ↑ 11.2-fold | ─ | ↑ 22.5-fold | ↑ 8.9-fold | ↑ 2-fold | ─ |
| TIPARP | PARP family | ↑ 5.5-fold | ─ | ↑ 5.8-fold | ↑ 2.9-fold | ↑ 6-fold | ↑ 4.7-fold |
| JUN | Cell proliferation | ↑ 5.5-fold | ↑ 1.8-fold | ↑ 5.1-fold | ↑ 3.6-fold | ─ | ─ |
| p21 | cell cycle checkpoints | ↑ 3.2-fold | ─ | ↑ 6.6-fold | ─ | ─ | ─ |
| RASAL1 | Ras regulator | ↑ 3.4-fold | ─ | ↑ 2.8-fold | ↑ 3.3-fold | ─ | ↓ 2.8-fold |
| RGC32 | Cell cycle control | ↑ 2.9-fold | ↑ 1.6-fold | ↑ 2.3-fold | ─ | ↑ 2.3-fold | ↑ 1.5-fold |
| ALDH1A3 | Xenobiotic metabolism | ↑ 1.7-fold | ─ | ↑ 4.2-fold | ↑ 4.3-fold | ↑ 2.4-fold | ─ |
| DLX2 | Development | ↑ 1.5-fold | ─ | ↑ 4.8-fold | ↑ 5-fold | ↑ 2.5-fold | ↑ 3.3-fold |
| CEBPA | Mitotic growth arrest | ↑ 1.7-fold | ─ | ─ | ─ | ↑ 1.5-fold | ↑ 1.7-fold |
| NRF2 | Oxidative stress | ↑ 1.5-fold | ─ | ─ | ─ | ↑ 1.6-fold | ↑ 1.6-fold |
| ATF3 | Transcription Factor | ↑ 3-fold | ─ | ↑ 6.1-fold | ↑ 4.5-fold | ─ | |
| DNAJB4 | Oxidative stress | ↑ 2.2-fold | ─ | ↑ 1.6-fold | ↑ 1.9-fold | ─ | ↑ 1.5-fold |
| Bax | Apoptosis | ↑ 1.5-fold | ─ | ↑ 1.6-fold | ─ | ─ | ↑ 1.6-fold |
| SPRY4 | MAPK signalling | ─ | ─ | ─ | ↑ 4.5-fold | ↑ 1.7-fold | ─ |
| GSTT2 | Xenobiotic metabolism | ↑ 2.8-fold | ↑ 1.7-fold | ─ | ─ | ─ | ─ |
| CABLES2 | Apoptosis | ─ | ─ | ─ | ─ | ─ | ↑ 2.3-fold |
| PTGER4 | T-cell factor signalling | ─ | ↑ 2.7-fold | ↑ 1.5-fold | ─ | ─ | ↑ 2.2-fold |
| BBC3 | Apoptosis | ─ | ─ | ↑ 2.1-fold | ↑ 5-fold | ─ | ↑ 1.9-fold |
| EGR1 | Cell growth and proliferation | ↑ 6.7-fold | ↑ 2.7-fold | ↑ 2.5-fold | ─ | ─ | ─ |
| CTNNB1 | Cell adhesion | ↑ 1.5-fold | ↑ 2.25-fold | ─ | ─ | ─ | ─ |
| PLK3 | Cell cycle control | ─ | ─ | ↑ 2.5-fold | ↑ 3.4-fold | ─ | ─ |
| AFF4 | Transcription Elongation | ─ | ─ | ─ | ↓ 2.6-fold | ↓ 1.5-fold | ↓ 6.2-fold |
| ZBRK1 | DNA damage response | ─ | ─ | ─ | ↓ 4.7-fold | ─ | ─ |
| DKK1 | Wnt/Catenin | ↓ 7-fold | ↓ 3.1-fold | ↓ 2.8-fold | ─ | ↓ 2.4-fold | ─ |
| KAT2B | Transcription regulation | ↓ 4.6-fold | ─ | ↓ 3-fold | ─ | ↓ 6.5-fold | ↓ 1.7-fold |
| RASGRP1 | Ras signalling | ↓ 3.8-fold | ↓ 1.5-fold | ↓ 2.2-fold | ─ | ↓ 6-fold | ↓ 2-fold |
| JMJD2C | Histone demethylase | ↓ 3.6-fold | ─ | ↓ 4.5-fold | ↓ 2-fold | ↓ 3-fold | ↓ 1.8-fold |
| HDAC4 | Cell cycle control | ↓ 2.1-fold | ─ | ↓ 2.7-fold | ↓ 1.8-fold | ↓ 1.8-fold | ─ |
| FERMT1 | Actin cytoskeleton | ↓ 2.1-fold | ↓ 6.7-fold | ↓ 1.8-fold | ─ | ↓ 2.5-fold | ─ |
| Scaper | cell cycle checkpoints | ↓ 1.8-fold | ↓ 1.5-fold | ↓ 1.8-fold | ↓ 2-fold | ↓ 2.8-fold | ↓ 2.2-fold |
| NPM1 | Cell proliferation/Apoptosis | ─ | ─ | ─ | ─ | ─ | ↑ 2.4-fold |
| YWHAQ | Cell cycle control/Apoptosis | ─ | ─ | ─ | ─ | ─ | ─ |
| AHR | Xenobiotic Metabolism | ─ | ─ | ─ | ─ | ─ | ─ |
| p53 | Tumour Suppressor | ─ | ─ | ─ | ─ | ─ | ─ |
| RFC5 | Replication Factor | ─ | ↑ 1.8-fold | ─ | ─ | ─ | ─ |
| Hint1 | Apoptosis | ─ | ↑ 2.2-fold | ─ | ─ | ─ | ↑ 1.5-fold |
| NQO1 | Xenobiotic metabolism | ─ | ↑ 2.2-fold | ─ | ─ | ─ | ─ |
A 1.5-fold cut-off was used. ↑ denotes up-regulation, and ↓ denotes down-regulation.