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. 2011 Jul 28;7(7):e1002177. doi: 10.1371/journal.pgen.1002177

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Bader et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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GWiS correctly identifies the SCN5A-SCN10A locus as genome-wide significant with four independent effects, even though the strongest single effect has a p-value 100 worse than the genome-wide significance threshold indicated as a dashed line. No other method was able to identify this locus as genome-wide significant. The SNPs selected by GWiS are represented as large, colored diamonds, and SNPs in LD with these four are colored in lighter shades. The light blue trace indicates recombination hotspots.

Inline graphic — GWiS correctly identifies the SCN5A-SCN10A locus as genome-wide significant with four independent effects, even though the strongest single effect has a p-value 100 worse than the genome-wide significance threshold indicated as a dashed line. No other method was able to identify this locus as genome-wide significant. The SNPs selected by GWiS are represented as large, colored diamonds, and SNPs in LD with these four are colored in lighter shades. The light blue trace indicates recombination hotspots.