Table 2. Loci associated with SNP markers with P-values <5.0×10−8.
| Most significant SNP | ||||||
| Fatty acid (region) | Analysis adjustments | Number of SNPs| | SNP*, allele | MAF | P-value | Parameter Coefficient (CI) |
| ALA (11) | Main model† | 75 | rs174547,C/T | 0.33 | 4×10−64 | 0.016 (0.014, 0.018) |
| ALA (11) | EPA‡ | 86 | rs174547,C/T | 0.33 | 7×10−84 | 0.019 (0.017, 0.021) |
| DPA (2) | Main model† | 3 | rs780094, T/C | 0.41 | 9×10−09 | 0.017 (0.011, 0.022) |
| DPA (6) | Main model† | 85 | rs3734398, C/T | 0.43 | 1×10−43 | 0.040 (0.035, 0.046) |
| DPA (6) | rs2236212, rs174547‡ | 22 | rs12662634, A/G | 0.18 | 3×10−10 | −0.023 (−0.039, −0.021) |
| DPA (11) | Main model† | 97 | rs174547,C/T | 0.33 | 4×10−154 | −0.075 (−0.069, −0.080) |
| EPA(6) | Main model† | 47 | rs3798713, C/G | 0.43 | 2×10−12 | 0.035 (0.025, 0.045) |
| EPA(6) | DHA‡ | 78 | rs3798713, C/G | 0.43 | 8×10−35 | 0.054 (0.045, 0.062) |
| EPA(6) | ALA‡ | 77 | rs3798713, C/G | 0.43 | 3×10−12 | 0.035 (0.025, 0.045) |
| EPA (11) | Main model† | 78 | rs174538, A/G | 0.28 | 5×10−58 | −0.083 (−0.094, −0.073) |
| EPA (11) | DHA‡ | 77 | rs174535, C/T | 0.31 | 2×10−59 | −0.072 (−0.063, −0.080) |
| EPA (11) | ALA‡ | 87 | rs174535, C/T | 0.31 | 1×10−84 | −0.097 (−0.088, −0.107) |
| DHA (6) | Main model† | 57 | rs2236212, C/G | 0.43 | 1×10−15 | −0.113 (−0.086, −0.141) |
| DHA (6) | EPA‡ | 76 | rs2236212, C/G | 0.43 | 7×10−39 | −0.162 (−0.138, −0.186) |
Results of the meta-analyses of n-3 fatty acid GWAS; main results with standard adjustments described in Methods, and additional results further adjusted for one other fatty acid or for selected SNPs.
†Adjustments of the cohort-specific GWAS; the main model included age, sex, and if appropriate study site and principal components to account for population structure.
‡Adjustment in addition to main model adjustments.
| Number of SNPs with p-values <5.0×10−8.
*The SNPs rs3798713, rs2236212 and rs3734398 are in perfect LD; rs174538, rs174535 and rs174547 are in LD with r2≥0.9. Positions for genome built 36.3 are 61327359 (rs174547), 27594741 (rs780094), 11090959 (rs3734398), 11182177 (rs12662634), 11116608 (rs3798713), 61316657 (rs174538), 61307932 (rs174535), 11103001 (rs2236212).