Table 4. Associations of rs3734398 (C allele) with n-3 polyunsaturated fatty acids in samples of different ancestries.

			ALA		EPA		DPA		DHA
	N	MAF	Beta* (SE)	p-value	Beta* (SE)	p-value	Beta* (SE)	p-value	Beta* (SE)	p-value
European ancestry cohort †
ARIC	3268	0.42	0.0002 (0.001)	0.87	0.028 (0.008)	2×10−04	0.042 (0.004)	4×10−24	−0.119 (0.022)	8×10−08
CARDIA	1507		−0.002 (0.003)	0.52	0.055 (0.022)	0.01	0.037 (0.008)	1×10−06	−0.090 (0.041)	0.03
CHS	2326	0.43	0.003 (0.002)	0.08	0.044 (0.010)	7×10−06	0.040 (0.005)	1×10−13	−0.144 (0.027)	2×10−07
InCHIANTI	1075	0.43	−0.0007 (0.009)	0.94	0.037 (0.010)	2×10−04	NA		−0.092 (0.032)	0.004
MESA	690	0.42	0.0001 (0.003)	0.98	0.014 (0.029)	0.06	0.041 (0.011)	2×10−04	−0.065 (0.068)	0.34
Overall‡	8866	0.43	0.0008 (0.001)	0.37	0.035 (0.005)	4×10−12	0.040 (0.003)	1×10−43	−0.114 (0.014)	2×10−15
African ancestry cohort
CARDIA	1493	0.25	−0.002 (0.004)	0.57	0.040 (0.017)	0.02	0.045 (0.008)	1×10−07	−0.077 (0.041)	0.06
CHS	426	0.25	0.003 (0.003)	0.37	−0.016 (0.022)	0.46	0.043 (0.013)	0.001	−0.191 (0.071)	0.008
MESA	628	0.25	−0.004 (0.004)	0.32	0.043 (0.035)	0.02	0.030 (0.013)	0.02	−0.042 (0.107)	0.69
Overall‡	2547	0.25	−0.0002 (0.002)	0.93	0.022 (0.013)	0.08	0.041 (0.006)	7×10−12	−0.099 (0.034)	0.003
Chinese ancestry cohort
MESA	633	0.92	−0.005 (0.008)	0.51	−0.097 (0.071)	0.17	−0.005 (0.026)	0.85	−0.200 (0.154)	0.20
Hispanic ancestry cohort
MESA	661	0.57	−0.002 (0.003)	0.56	−0.006 (0.021)	0.79	0.033 (0.012)	0.01	−0.110 (0.055)	0.05

For each fatty acid, results are shown for the individual cohorts and for the meta-analyses among samples of European ancestry and samples of African ancestry.

*Beta-regression coefficient associated with one copy of the G allele.

†Included in the GWAS.

‡Meta-analysis of results of same ancestry cohorts.