Skip to main content
. 2011 Jul 28;6(7):e22730. doi: 10.1371/journal.pone.0022730

Table 4. Genes downregulated in the HIV-1 infected culture compared to uninfected control cells determined by transcriptome analysis.

Pathways # p Value Gene
Cell cycle 10 1.80E-10 MCM2; MCM7; PKMYT1; CDK2; GADD45B; MAD2L2; TFDP1; GADD45A; PCNA; ORC1L
Apoptosis 8 7.26E-09 IRAK2; NFKBIA; BCL2L1; TNFRSF10B; BAX; DFFA; EXOG; TNF
Purine metabolism 8 4.74E-07 ADA; ADCY3; ADCY8; POLA1; POLR3K; POLE2; GART; DGUOK
MAPK signaling 8 3.71E-05 MAP3K8; GADD45B; DUSP2; ATF4; GADD45A; DUSP5; TNF; DUSP10
Cytokine-cytokine receptor interaction 7 1.92E-04 TNFSF9; TNFRSF10B; CD70; IL8; TNF; TNFRSF18; TNFSF13B
DNA polymerase 5 5.76E-07 MCM2; MCM7; POLA1; PCNA; POLE2
Base excision repair 5 5.76E-07 PARP2; PCNA; POLE2; APEX2; POLB
Adipocytokine signaling 5 1.32E-05 SOCS3; NFKBIA; TNF; NFKBIE; CPT1A
p53 signaling 5 1.52E-05 CDK2; GADD45B; TNFRSF10B; BAX; GADD45A
Epithelial cell signaling in H.pylori infection 5 1.63E-05 NFKBIA; LYN; IL8; JAM2; SRC
Small cell lung cancer 5 4.44E-05 NFKBIA; BCL2L1; CDK2; TRAF3; TRAF4
Toll-like receptor signaling 5 1.00E-04 NFKBIA; MAP3K8; IL8; TNF; TRAF3
One carbon pool by folate 4 6.80E-07 SHMT2; GART; MTHFS; MTHFD1L
Urea cycle andmetabolism of amino groups 4 7.33E-06 ASS1; ACY1; ALDH7A1; SMS
Aminoacyl-tRNA biosynthesis 4 3.46E-05 WARS; YARS; GARS; RARS
Glycine, serine and threonine metabolism 4 4.19E-05 CBS; PHGDH; SHMT2; GARS
Gap junction 4 8.33E-04 ADCY3; ADCY8; CSNK1D; SRC
Pyrimidine metabolism 4 8.33E-04 UPP1; POLA1; POLR3K; POLE2
GnRH signaling 4 0.00140 ADCY3; ADCY8; ATF4; SRC
T cell receptor signaling 4 0.00150 NFKBIA; MAP3K8; TNF; NFKBIE
Tight junction 4 0.00335 CGN; MYL2; JAM2; SRC
Insulin signaling 4 0.00353 TRIP10; SOCS3; PFKM; PTPN1
Mismatch repair 3 1.46E-04 MSH6; PCNA; EXO1
Arginine and proline metabolism 3 5.66E-04 ASS1; PYCR1; RARS
Nucleotide excision repair 3 0.00102 ERCC1; PCNA; POLE2
Fatty acid metabolism 3 0.00109 ACADVL; ALDH7A1; CPT1A
Glutathione metabolism 3 0.00148 GSTA4; GGCT; SMS
Inositol phosphate metabolism 3 0.001952 IMPA2; INPP1; ITPKA
Amyotrophic lateral sclerosis 3 0.002056 BCL2L1; BAX; TNF
Hedgehog signaling 3 0.002163 CSNK1E; CSNK1D; RAB23
Glycolysis/Gluconeogenesis 3 0.003010 ALDH7A1; PFKM; GCK
Drug metabolism cytochrom.p450 3 0.00419 GSTA4; FMO4; CYP3A5
B-cell receptor signaling 3 0.0047 NFKBIA; LYN; NFKBIE
Chronic myeloid leukemia 3 0.0047 NFKBIA; BCL2L1; STAT5A
Phosphatidylinositol signaling 3 0.0048 IMPA2; INPP1; ITPKA
Prostate cancer 3 0.0073 NFKBIA; CDK2; ATF4
NK cell mediated cytotoxicity 3 0.0243 TNFRSF10B; ULBP1; TNF
Jak-STAT signaling 3 0.0327 SOCS3; BCL2L1; STAT5A
Calcium signaling 3 0.0501 ADCY3; ADCY8; ITPKA
Focal adhesion 3 0.0649 MYL2; SRC; PARVB