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. 2011 Jul 11;108(30):12455–12460. doi: 10.1073/pnas.1104361108

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Fig. 4. — Allelic disruption of Beclin1 suppresses spontaneous renal tumorigenesis in Tsc2 heterozygous mice. (A) The kidney with the most severe lesions from each genotype is shown; arrows indicate cystadenomas. (B) Macroscopic tumor scores from WT (wt), Tsc2^+/− (T2^+/−), Beclin1^+/− (B1^+/−), and Tsc2^+/−Beclin1^+/− (T2^+/−B1^+/−) littermates (n = 8 kidneys per genotype). No tumors were observed in WT or Beclin1^+/− mice. *P < 0.05. (C) Representative H&E-stained lesions. N, normal kidney. T, cystadenomas. (Original magnification, 20×.) (D) Microscopic tumor scores. *P < 0.05.