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. 2011 Jul 28;6(7):e22733. doi: 10.1371/journal.pone.0022733

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Walker et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Lim 1899 cells expressing siRNA to LGR5 (siLGR5) or the pTune/LGR5 construct (LGR5) were seeded on chamber slides, fixed and stained with rhodamine-phalloidin (red) or anti-CD44 followed by Alexa 488 anti-rat (green). Nuclei were stained with DAPI (blue). A): typical patterns of CD44 localization in the different cells. B) micrographs selected to show the focal actin rings and their coincidence (vector, LGR5) or lack of coincidence (siLGR5) with CD44. The lower panels show enlarged areas of the micrograph, highlighting the actin structures associated with CD44. In these panels actin staining and CD44 staining are shown separately in greyscale.