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. 2011 Jul 28;6(7):e22852. doi: 10.1371/journal.pone.0022852

Figure 3. Disturbance rejection (fluctuation filtering).

Figure 3

(A) A system receives the input signal in the presence of an external disturbance (shown in blue). As a result, the system generates the output affected by both the input and external disturbance. (B) The external disturbance effects can be filtered (removed) by adding a negative feedback loop and a controller (shown in red) to the system. (C) It is shown that NUMB (input) activates p53 (system) in the presence of fluctuations exerted on p53. (D) MDM2 (controller) and a feedback loop are added to the NUMB-p53 network shown in (C). As a result, the NUMB signal (input) transmitted to p53 (system) is reflected on the output without being affected by fluctuations exerted on p53.