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. 2011 Jul 28;6(7):e22852. doi: 10.1371/journal.pone.0022852

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Shin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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At top left, x is assumed to be constant ( = 1000 molecules/cell). On the left of the figure, it is shown that intrinsic noise (period T = 1 min and amplitude = 100 molecules/cell) is filtered by the feedback loop. Periodic DNA repair-related fluctuation (period T = 40 min) with the same amplitude (100 molecules/cell) is also filtered as shown on the right.