Figure 3. Removal of the gonads reduces the sex difference in influenza pathogenesis.

Rectal temperature (A) and survival (B) were monitored for 21 days after inoculation of intact (sham) male (n = 18), sham female (n = 20), gonadectomized (gdx) male (n = 12), or gdx female (n = 9) mice with PR8. Data represent the mean ± SEM. Significant differences between sham males and females as determined by post hoc analyses at each time-point are represented by an asterisk (*), P<0.05. Significant differences between intact and gdx males as determined by post hoc analyses at each time-point are represented by a number symbol (#), P<0.05.