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. 2011 Jul 28;7(7):e1002142. doi: 10.1371/journal.ppat.1002142

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A. Cartoon showing the locations of the 2 open reading frames encoding the nonstructural proteins and the subgenomic message encoding the capsid (C) as well as the envelope glycoproteins E2 and E1. B. Inactivation of the subgenomic promoter and insertion of the encephalomyocarditis internal ribosome entry site (IRES) to drive expression of the structural proteins from the genomic message. C. Wild-type subgenomic promoter (above) and inactivated promoter sequence (below) with synonymous mutations in lower-case. Deduced amino acid sequence is between nucleotide sequences. Red letters represent the subgenomic promoter region.