Table 2.

Effect of SLC6A4 methylation and number of traumatic events on risk of lifetime posttraumatic stress disorder diagnosis

	Main Effects Model −2 Log L = 93.268				Interaction Model −2 Log L = 87.619
	b	p	95% CI of b		b	p	95% CI of b
Intercept	−2.7355	0.0074	−4.7366	0.7343	−2.5973	0.0113	−4.6059	−0.5886
centered SLC6A4 methylation beta-value	−2.9250	0.1878	−7.2777	1.4278	−0.3743	0.8845	−5.4253	4.6768
Number of traumatic events	0.1218	0.1159	−0.0300	0.2736	0.1638	0.0669	−0.0114	0.3391
Age	0.00329	0.8489	−0.0306	0.0372	0.00612	0.7397	−0.0300	0.0422
sex	0.5428	0.3622	−0.6247	1.7103	0.7154	0.2500	−0.5036	1.9344
African American	−0.1657	0.8044	−1.4775	1.1461	−0.4456	0.5290	−1.8328	0.9416
Ever smoke	1.0813	0.0792	−0.1262	2.2888	1.0194	0.1136	−0.2435	2.2824
PBMC	−0.0120	0.6990	−0.0726	0.0487	−0.00530	0.8644	−0.0662	0.0556
Depression diagnosis	1.0446	0.0597	−0.0428	2.1320	1.1343	0.0517	−0.00854	2.2772
SLC6A4 sl genotype	0.3284	0.6004	−0.9005	1.5573	0.2726	0.6752	−1.0026	1.5479
SLC6A4 ss genotype	−0.1116	0.8864	−1.6427	1.4194	0.1072	0.8946	−1.4781	1.6924
SLC6A4 methylation * number of traumatic events					−1.5596	0.0360	−3.0170	−0.1022

Note: PBMC = peripheral blood mononuclear cells

Note: 's' allele includes S and Lg; 'l' allele includes La and XL

Note: continuous variables were centered to the mean