Table 3.

Effect of SLC6A4 methylation and number of traumatic events on risk of lifetime posttraumatic stress disorder symptom severity

	Main Effects Model Adjusted R-square = 0.2791				Interaction Model Adjustted R-square = 0.3051
	b	p	95% CI of b		b	p	95% CI of b
Intercept	3.17171	<.0001	2.90733	3.43608	3.19094	<.0001	2.93069	3.45120
centered SLC6A4 methylation beta-value	−0.08024	0.7899	−0.67686	0.51638	0.11063	0.7210	−0.50296	0.72422
Number of traumatic events	0.04389	0.0001	0.02192	0.06585	0.04848	<.0001	0.02647	0.07050
Age	−0.00186	0.4215	−0.00642	0.00271	−0.00158	0.4873	−0.00607	0.00291
sex	0.16367	0.0439	0.00457	0.32277	0.18439	0.0223	0.02691	0.34188
African American	0.09231	0.3226	−0.09207	0.27669	0.07555	0.4110	−0.10621	0.25732
Ever smoke	0.11959	0.1441	−0.04165	0.28083	0.10766	0.1812	−0.05108	0.26641
PBMC	0.00700	0.1331	−0.00217	0.01617	0.00745	0.1041	−0.00157	0.01647
Depression diagnosis	0.18103	0.0262	0.02197	0.34009	0.17302	0.0305	0.01664	0.32940
SLC6A4 sl genotype	0.13842	0.1144	−0.03408	0.31091	0.13951	0.1053	−0.02988	0.30890
SLC6A4 ss genotype	0.15616	0.1327	−0.04831	0.36063	0.18129	0.0783	−0.02093	0.38350
SLC6A4 methylation * number of traumatic events					−0.15546	0.0404	−0.30398	−0.00694

Note: PBMC = peripheral blood mononuclear cells

Note: 's' allele includes S and Lg; 'l' allele includes La and XL

Note: continuous variables were centered to the mean