Table 4.

Effect of SLC6A4 methylation and number of traumatic events on risk of lifetime number of posttraumatic stress disorder symptoms

	Main Effects Model −2 Log L = 540.0076				Interaction Model −2 Log L = 543.69
	b	p	95% CI of b		b	p	95% CI of b
Intercept	0.6600	0.0406	0.0283	1.2916	0.6755	0.0340	0.0509	1.3001
centered SLC6A4 methylation beta-value	−0.0361	0.9590	−1.4097	1.3375	0.6208	0.4017	−0.8301	2.0718
Number of traumatic events	0.1012	0.0001	0.0498	0.1526	0.1170	<.0001	0.0659	0.1682
Age	−0.0027	0.6290	−0.0135	0.0082	−0.0017	0.7513	−0.0123	0.0089
sex	0.3853	0.0407	0.0164	0.7542	0.4196	0.0230	0.0578	0.7814
African American	0.4105	0.0764	−0.0435	0.8644	0.3844	0.0890	−0.0586	0.8273
Ever smoke	0.1836	0.3346	−0.1894	0.5566	0.1649	0.3707	−0.1961	0.5258
PBMC	0.0110	0.2867	−0.0093	0.0314	0.0130	0.2035	−0.0070	0.0330
Depression diagnosis	0.3553	0.0576	−0.0115	0.7221	0.3737	0.0411	0.0152	0.7321
SLC6A4 sl genotype	0.4177	0.0426	0.0140	0.8215	0.4108	0.0419	0.0150	0.8067
SLC6A4 ss genotype	0.3265	0.1801	−0.1509	0.8039	0.3803	0.1128	−0.0897	0.8503
SLC6A4 methylation * number of traumatic events					−0.4122	0.0184	−0.7548	−0.0695

Note: PBMC = peripheral blood mononuclear cells

Note: 's' allele includes S and Lg; 'l' allele includes La and XL

Note: continuous variables were centered to the mean