Fig. 2.

The expression of miRNAs predicted to target CCN3 decreases with BCR-ABL reduction. Analysis of BCR-ABL dependent miRNA expression of K562 cells was carried out using TLDA miRNA cards. The miRNA expression of K562 cells transfected with siRNA directed against BCR-ABL was compared with the control K562 cells at 24 h and 72 h post transfection. Data represents the fold reduction observed in the expression of 5 miRNAs predicted to target CCN3 with each BCR-ABL silencing experiment (n = 3), *, p < 0.05; ***, p < 0.001. The expression of RNU48 was used as the endogenous control. Light bars represent 24 h and dark bars represent 72 h time points