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. 2011 Mar 14;30(30):3360–3369. doi: 10.1038/onc.2011.55

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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BRC5 overexpression in cells inhibits the interaction between BRCA2 and HMG20b, whereas BRC4 does not. (a) HeLa TetOn cell clones stably expressing either myc-tagged BRC4 (clone 4.23) or BRC5 (clones 5.10) were induced by doxycycline treatment, and the expression of myc-BRC4 or -BRC5 was analyzed by western blotting with anti-myc antibody. β-Actin was used as a loading control. (b) BRCA2-associated protein complexes were immunoprecipitated from myc-BRC4- or -BRC5-expressing cells using protein A-coupled anti-BRCA2 antibody (αB2-9), and western blotted with anti-HMG20b or anti-RAD51 antibodies, as shown.