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. 2011 Mar 14;30(30):3360–3369. doi: 10.1038/onc.2011.55

Figure 6.

Figure 6

A model for the divergent tumor-suppressive functions of the BRC repeats of BRCA2. In a schematic depiction of human BRCA2, the gray circle highlights the evolutionarily conserved region that contains eight BRC repeats whose sequence and spacing are preserved among mammalian orthologues. Most BRC repeats, including BRC4, are known to bind and control the RAD51 recombinase in reactions that lead to homologous DNA recombination. BRC5 (but not BRC4) binds directly to HMG20b, and this interaction regulates an unrecognized function for HMG20b in the efficient completion of cell division by cytokinesis. Thus, divergent tumor-suppressive functions maintaining chromosome segregation as well as chromosome structure may be mediated by the conserved BRC repeats of BRCA2.