Fig. 1.

a Effect of cyclic nucleotide lipophilicity on cell membrane permeability in platelets. Error bars represent SD of three independent experiments. Shown are the data for 8-Br-cGMP (analog 15), 8-pCPT-cGMP (analog 16) and 8-Br-PET-cGMP (analog 22). b Time-dependent influx of cyclic nucleotides. Platelets were incubated with 3nM 8-pCPT-cGMP (analog 16) or 8-Br-PET-cGMP (analog 22) for the time points indicated, and the intracellular analog concentration was measured. Error bars represent SD of two independent experiments in duplicate