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. Author manuscript; available in PMC: 2012 Jul 28.
Published in final edited form as: Neuron. 2011 Jul 28;71(2):319–331. doi: 10.1016/j.neuron.2011.05.038

Figure 5. Mutant cycle analysis for interactions between intermolecular contacts in the heterodimer assembly.

Figure 5

(A) The KA2 subunit ATD viewed face on to the heterodimer surface, indicating the position of Tyr57 in site 1; Glu156 in site 2; Ile164 in site 3; Ser165 and Thr168 in site 4 that stabilizes the loop which makes site 3 contacts; the Cys64-Cys315 disulfide bond which holds loop 3 in place; and the location of Lys148 and Glu150. (B) Illustration of a mutant cycle for coupling between two sites indicated as A and B. (C) Amino acid alignment for AMPA and kainate receptors reveals a unique conservation of Ile164 in the KA2 subunits, and exchange of conserved residues in the loop connecting alpha helix F with beta strand 7.