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. 2011 May 3;589(Pt 13):3071–3083. doi: 10.1113/jphysiol.2011.209700

Figure 5. Kir6.2ΔC-W68Y currents have reduced ATP sensitivity.

Figure 5

Mean relationship between [ATP] and KATP current (I), expressed relative to the current in the absence of nucleotide (Ic) for Kir6.2/SUR1 (open triangles, Mg-free, n = 9), Kir6.2/SUR1 (open squares, with Mg2+, n = 26), Kir6.2-W68Y/SUR1 (filled triangles, Mg-free, n = 4), Kir6.2-W68Y/SUR1 (filled squares, with Mg2+, n = 8), Kir6.2ΔC (open circles, with Mg2+, n = 5) and Kir6.2ΔC-W68Y/SUR1 channels (filled circles, with Mg2+, n = 5). The smooth curves are the best fit of eqn (1) to the data: Kir6.2/SUR1 (Mg-free; IC50 = 10 μm, h = 1.15), Kir6.2/SUR1 (with Mg2+, IC50 = 15 μm, h = 1.01), Kir6.2-W68Y/SUR1 (Mg-free, drawn by eye), Kir6.2-W68Y/SUR1 (with Mg2+, drawn by eye), Kir6.2ΔC (with Mg2+, IC50 = 144 μm, h = 1.08) and Kir6.2ΔC-W68Y/SUR1 channels (with Mg2+, IC50 = 1.5 mm, h = 1.14).