Table 3.
Core Signaling and Processes Alterted in CHF1 Transgenic Hearts after Banding
| Regulatory process or pathway | Representative altered genes |
|---|---|
| GO:0048661 (regulation of smooth muscle cell proliferation) | EGFR, GNAQ, HBEGF |
| GO:0007369 (gastrulation) | SLIT2, PRKAR1A, TBX6, BMP4, KLF4, SHH |
| GO:0001704 (formation of primary germ layer) | SLIT2, PKAR1A, TBX6, BMP4, KLF4, SHH |
| GO:0042095 (IFN-gamma biosynthesis) | TLR3, TLR8, TLR7,IL18 |
| GO:0045088 (regulation of innate immune response) | TLR8, TLR4, TLR3 |
| GO:0045089 (positive regulation of innate immune response) | TLR8, TLR4, TLR3 |
| GO:0045078 (positive regulation of interferon-gamma biosynthetic process) | TLR8, TLR3, TLR7 |
| GO:0032069 (negative regulation of response to food) | CCK, PYY, CRHR1, CARTPT |
| MCALPAINPATHWAY | PRKAR1A, PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| AGPCRPATHWAY | PRKAR1A, PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| BADPATHWAY | PRKAR1A, PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| SHHPATHWAY | PRKAR1A, PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| CHREBPPATHWAY | PRKAR1A, PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PTEN |
| SIG_CHEMOTAXIS | PTEN |
| TUMOR_SUPRESSOR | PTEN |
| BCL2_FAMILY_AND_REG_NETWORK | APAF1, CASP8 |
| MITOCHONDRIAPATHWAY | APAF1, CASP8 |