Table 2.
Association of MICA/HCP5 deletion and NPC in an independent set of case–control samples
| Characteristica | Discovery phase |
P-valueb | Validation phase |
P-valueb | Combined |
P-valueb | Odds ratio (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 276) | NPC patients (n = 275) | Controls (n = 458) | NPC patients (n = 428) | Controls (n = 734) | NPC patients (n = 703) | |||||
| With deletion | 0 (0%) | 11 (4%) | 4.32E–04 | 5 (1.1%) | 13 (3%) | 0.0548 | 5 (0.7%) | 24 (3.4%) | 2.27E–04 | 5.15 (1.96–13.58) |
| Without deletion | 276 (100%) | 264 (96%) | 453 (98.9%) | 415 (97%) | 729 (99.3%) | 679 (96.6%) | ||||
| Male | 183 | 207 | 0.0081 | 316 | 312 | 0.003 | 499 | 519 | 3.65E–05 | 18.92 (2.52–141.91) |
| With deletion | 0 (0%) | 8 (3.9%) | 1 (0.3%) | 11 (3.5%) | 1 (0.2%) | 19 (3.7%) | ||||
| Without deletion | 183 (100%) | 199 (96.1%) | 315 (99.7%) | 301 (96.5%) | 498 (99.8%) | 500 (96.3%) | ||||
| Female | 93 | 68 | 0.0734 | 142 | 116 | 0.694 | 235 | 184 | 0.514 | 1.61 (0.43–6.09) |
| With deletion | 0 (0%) | 3 (4.4%) | 4 (2.8%) | 2 (1.7%) | 4 (1.7%) | 5 (2.7%) | ||||
| Without deletion | 93 (100%) | 65 (95.6%) | 138 (97.2%) | 114 (98.3%) | 231 (98.3%) | 179 (97.3%) | ||||
a‘Deletion’ means the MICA/HCP5 deletion (CN = 1) in this case.
bStatistical significance was determined using Fisher's exact test; values of P < 0.05 are shown in bold.