Table 2.

Summary of haemodynamic parameters in wild-type and RIP2^−/− mouse hearts perfused with or without muramyl dipeptide for 15 min after the ischaemic period, associated or not with a TAK1 inhibitor (5Z-7-oxozeanol)

Treatment	n	Body weight (g)	Heart weight (mg)	LVDP (mmHg)			LVEDP (mmHg)			CF (mL/min)
				Baseline	60 min Rep	120 min Rep	Baseline	60 min Rep	120 min Rep	Baseline	60 min Rep	120 min Rep
WT	8	25.1 ± 1.5	135.5 ± 4.9	68.6 ± 2.2	7.0 ± 1.8	10.0 ± 2.4	4.4 ± 0.9	56.0 ± 1.3	45.3 ± 1.1	2.7 ± 0.2	1.4 ± 0.2	1.4 ± 0.2
WT + MDP	8	24.8 ± 1.2	134.5 ± 3.4	68.0 ± 1.8	15.6 ± 3.8*	19.9 ± 3.3*	6.1 ± 0.5	43.0 ± 4.7*	31.9 ± 3.3*	2.3 ± 0.1	1.3 ± 0.1	1.2 ± 0.1
RIP2−/−	6	26.1 ± 1.8	135.5 ± 6.2	74.5 ± 1.1	4.3 ± 2	7.2 ± 2.1	3.7 ± 0.8	58.7 ± 6.0	46.2 ± 6.9	2.7 ± 0.1	1.3 ± 0.1	1.1 ± 0.1
RIP2−/− + MDP	6	25.9 ± 1.4	139.4 ± 5.2	74.0 ± 1.6	9.0 ± 4$	7.8 ± 3.8	5.0 ± 1.1	58.8 ± 4.4	49.2 ± 5.3	2.7 ± 0.1	1.4 ± 0.2	1.1 ± 0.1
WT + 5-oxo	5	25.9 ± 2.3	133.3 ± 5.4	69.2 ± 1.5	4.6 ± 1.3	8.6 ± 1.7	3.4 ± 0.6	54.2 ± 1.7	52.0 ± 7.3	2.3 ± 0.1	1.1 ± 0.1	1.0 ± 0.1
WT + 5-oxo + MDP	5	26.5 ± 2.1	136.4 ± 6.3	73.6 ± 2.8	3.6 ± 1.7#	9.2 ± 2.3#	2.4 ± 0.4	50.8 ± 3.0	46.0 ± 4.1	2.4 ± 0.4	0.9 ± 0.1	0.8 ± 0.1
RIP−/− + 5-oxo	6	26.9 ± 1.5	142.1 ± 9.4	79.0 ± 3.7	5.5 ± 1.4	5.3 ± 1.7	6.3 ± 1.0	62.0 ± 2.7	58.2 ± 4.0	2.9 ± 0.3	1.6 ± 0.2	1.3 ± 0.2
RIP2−/− + 5-oxo + MDP	6	26.8 ± 1.2	136.2 ± 10.4	77.2 ± 2.8	7.2 ± 0.9	6.2 ± 1.1	5.8 ± 0.6	60.6 ± 5.1	55.6 ± 4.3	2.9 ± 0.2	1.7 ± 0.3	1.4 ± 0.2

Values are means ± SEM. Left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), and coronary flow (CF) were measured after 30 min of stabilization (baseline), and at 60 min (Rep 60 min) and 120 min (Rep 120 min) after the onset of reperfusion.

*P < 0.01 WT vs. WT + MDP.

^$P < 0.01 WT + MDP vs. RIP2^−/− + MDP.

^#P < 0.01 WT + MDP vs. WT + MDP + 5-oxo.