Table 2.
Treatment | n | Body weight (g) | Heart weight (mg) | LVDP (mmHg) |
LVEDP (mmHg) |
CF (mL/min) |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 60 min Rep | 120 min Rep | Baseline | 60 min Rep | 120 min Rep | Baseline | 60 min Rep | 120 min Rep | ||||
WT | 8 | 25.1 ± 1.5 | 135.5 ± 4.9 | 68.6 ± 2.2 | 7.0 ± 1.8 | 10.0 ± 2.4 | 4.4 ± 0.9 | 56.0 ± 1.3 | 45.3 ± 1.1 | 2.7 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.2 |
WT + MDP | 8 | 24.8 ± 1.2 | 134.5 ± 3.4 | 68.0 ± 1.8 | 15.6 ± 3.8* | 19.9 ± 3.3* | 6.1 ± 0.5 | 43.0 ± 4.7* | 31.9 ± 3.3* | 2.3 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 |
RIP2−/− | 6 | 26.1 ± 1.8 | 135.5 ± 6.2 | 74.5 ± 1.1 | 4.3 ± 2 | 7.2 ± 2.1 | 3.7 ± 0.8 | 58.7 ± 6.0 | 46.2 ± 6.9 | 2.7 ± 0.1 | 1.3 ± 0.1 | 1.1 ± 0.1 |
RIP2−/− + MDP | 6 | 25.9 ± 1.4 | 139.4 ± 5.2 | 74.0 ± 1.6 | 9.0 ± 4$ | 7.8 ± 3.8 | 5.0 ± 1.1 | 58.8 ± 4.4 | 49.2 ± 5.3 | 2.7 ± 0.1 | 1.4 ± 0.2 | 1.1 ± 0.1 |
WT + 5-oxo | 5 | 25.9 ± 2.3 | 133.3 ± 5.4 | 69.2 ± 1.5 | 4.6 ± 1.3 | 8.6 ± 1.7 | 3.4 ± 0.6 | 54.2 ± 1.7 | 52.0 ± 7.3 | 2.3 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 |
WT + 5-oxo + MDP | 5 | 26.5 ± 2.1 | 136.4 ± 6.3 | 73.6 ± 2.8 | 3.6 ± 1.7# | 9.2 ± 2.3# | 2.4 ± 0.4 | 50.8 ± 3.0 | 46.0 ± 4.1 | 2.4 ± 0.4 | 0.9 ± 0.1 | 0.8 ± 0.1 |
RIP−/− + 5-oxo | 6 | 26.9 ± 1.5 | 142.1 ± 9.4 | 79.0 ± 3.7 | 5.5 ± 1.4 | 5.3 ± 1.7 | 6.3 ± 1.0 | 62.0 ± 2.7 | 58.2 ± 4.0 | 2.9 ± 0.3 | 1.6 ± 0.2 | 1.3 ± 0.2 |
RIP2−/− + 5-oxo + MDP | 6 | 26.8 ± 1.2 | 136.2 ± 10.4 | 77.2 ± 2.8 | 7.2 ± 0.9 | 6.2 ± 1.1 | 5.8 ± 0.6 | 60.6 ± 5.1 | 55.6 ± 4.3 | 2.9 ± 0.2 | 1.7 ± 0.3 | 1.4 ± 0.2 |
Values are means ± SEM. Left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), and coronary flow (CF) were measured after 30 min of stabilization (baseline), and at 60 min (Rep 60 min) and 120 min (Rep 120 min) after the onset of reperfusion.
*P < 0.01 WT vs. WT + MDP.
$P < 0.01 WT + MDP vs. RIP2−/− + MDP.
#P < 0.01 WT + MDP vs. WT + MDP + 5-oxo.