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. Author manuscript; available in PMC: 2011 Jul 29.
Published in final edited form as: Curr Opin Genet Dev. 2009 Jan 21;19(1):60–66. doi: 10.1016/j.gde.2008.12.001

Figure 2. Mechanisms whereby HIF-2α contributes to an aggressive tumor phenotype.

Figure 2

A, HIF-2α activates expression of genes involved in proliferation, angiogenesis, metastasis, and differentiation. Regulation of TWIST by HIF-2α seems to be controversal. B, HIF-2α selectively activates expression of unknown gene X, which may enhance binding of polysomes to EGFR mRNA and subsequently its translation efficiency. C, HIF-2α enhances c-Myc activities by stabilizing c-Myc-Max complexes, increasing expression of c-Myc targets involved in cell cycle progression. See text for details.