Figure 2.

Structures of TLR2–TLR1/6 heterodimers induced by lipopeptides. (A) Crystal structure of TLR1/2–Pam₃CSK₄ complex. TLR1, TLR2, and Pam₃CSK₄ are colored in sandy brown, hot pink, and black, respectively. (B) Lipid-binding pocket in TLR1/2–Pam₃CSK₄ complex. The structures of TLRs are omitted to reveal the shape of lipid-binding pocket. (C) Crystal structure of TLR2/6–Pam₂CSK₄ complex. TLR2, TLR6, and Pam₂CSK₄ are colored in hot pink, gray, and deep magenta, respectively. (D) Lipid-binding pocket in TLR1/2–Pam₂CSK₄ complex. The lipid-binding channel is blocked by F343 and F365.