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Binding affinities for binding pocket mutants.
| RNA | Kd (nM) | ΔΔGbind (kcal/mol) |
|---|---|---|
| Vc2 110 (Wild-type) | 0.011 | 0 |
|
| ||
| G20A | 0.21 ± 0.067 | 1.8 |
| G20C | 3.9 ± 0.18 | 3.5 |
| G20U | 330 ± 150 | 6.1 |
|
| ||
| C92A | 97 ± 15 | 5.4 |
| C92G | 21000 ± 5800 | 8.6 |
| C92Ua | 15 ± 1.1 | 4.3 |
|
| ||
| A47C | 8500 ± 3000 | 8.0 |
| A47G | 4200 ± 1700 | 7.6 |
| A47U | 3500 ± 520 | 7.5 |
All values reported for C92U were reported previously (21).
