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Binding affinities for c-di-GMP riboswitch mutants mutants with disrupted tertiary contacts.
| RNA | Kd (nM) | ΔΔGbind (kcal/mol) |
|---|---|---|
| Wild-type | 0.011 | 0 |
|
| ||
| C44U | 1500 ± 460 | 7.0 |
| C44U/G83A | 190 ± 8.6 | 5.8 |
| C44G | 250 ± 5.2 | 5.9 |
|
| ||
| GUAA | 2.2 ± 0.77 | 3.1 |
| Helical | <0.5a | < 2.3 |
| UUCG | 11 ± 1.8 | 4.1 |
This value could not be measured using equilibrium methods and an upper estimate is given.
