Table 1.

Characteristics of Subjects

Control subject N	Age/gender/race	PMI	Storage time (months)a	Cause of death	Psychotropic medicationb	Drugs/alcoholc	Toxicology
1c	27/F/C	15	73	N	None	None	None detected
2c	30/M/AAm	19	63	N	None	None	None detected
3c	35/M/C	25	66	N	None	None	lidocaine
4c	37/F/C	13	41	N	None	None	prochlorperazine
5c	43/M/C	23	57	N	None	None	propoxyphene,
							norpropoxyphene,
							oxycodone
6c	46/F/C	27	77	H	None	None	None detected
7c	46/M/AAm	11	58	N	None	AA for 3 years.	None detected
						Not at the time of death
8c	50/F/C	27	65	N	None	None	None detected
9c	54/M/AAm	17	66	N	clonazepamd	None	brompheniramine
10c	60/F/AAm	19	85	N	None	None	None detected
11c	70/M/C	29	72	N	clonazepamb,e	AA 30 years ago	None detected
12c	71/M/C	24	95	N	None	AD for 20 years.	None detected
						Stopped 32 yearrs ago
13c	77/M/C	24	87	N	None	None	None detected
14c	80/F/C	21	58	N	None	None	None detected
15c	86/F/C	18	45	N	None	None	diltiazem, sodium 124, potassium 9.3
Average	54.1 ± 18.3		20.80 ± 5.21	67.47 ± 14.98

Major depressive disorder subject N	Age/gender/race	PMI	Storage time (months)a	Cause of death	Psychotropic medicationb	Drugs/Alcoholc	Toxicology	Duration of depression (years)f	Age of onset
1	34/F/C	27	67	S	trazodone,	None	CO, alprazolam	20	14
					alprazolam,b
					risperidone
2g	30/M/AAm	18	93	S	None	AA for 4 years.	EtOH	3	27
						Not at the time of death
3	36/M/C	11	46	U	None	None	diphenhydramine,	3	33
4h	40/F/C	25	66	HEART, other acc.OD	temazepam,b	DA	mophine, codeine,	3	35
					fluoxetineb		hydrocodone,
							diphenylhydramine
5	42/F/C	24	89	S	fluoxetine,b	DA	propoxyphene,	26	15
					amitriptyline,b		acetaminophen
					paroxetine,b
					diazepamb
6	42/M/C	20	82	S	sertralineb	None	sertraline,	2	40
							diphenylhydramine
7	46/M/AAm	17	89	H	None	None	None detected	1	45
8	50/F/C	23	82	S	clomipramine,	None	None detected	4	45
					fluoxetine,
					thiothixene
9	54/M/C	23	89	Ac	sertralineb	None	CO, phenobarbital,	3	51
							phenytoin
10	63/F/C	24	88	N	chlorpromazine,b	PS (20 years),		30	33
					clonazepam,b	AD(25 years)
					amitriptylineb
11g	73/F/C	17	81	N	lithium,b	AD for 40 years.	None detected	50	23
					nortriptyline,	Stopped 8 years before death
					restoril,
					clonazepamb
12	73/M/C	10	95	S	nortriptylineb	None	nortriptyline, EtOH	5	69
13	74/M/C	25	81	S	chlorpromazine,	PS	diazepam,	24	50
					trazodone,		acetaminophen
					clorazepate,
					methylphenidate
14	78/F/C	25	83	S	lorazepam	None	None detected	5	73
15	86/M/C	21	81	S	fluoxetine,b	None	None detected	30	55
					atenolol
Average	54.7717.6		20.6774.98	80.67712.27

AA, alcohol abuse; AAm, African American; Ac, accident; AD, alcohol dependence; C, caucasian; CO, carbon monoxide; D, drug abuse; DA, drug addiction; F, female; H, homicide; Hx, history; M, male; N, natural; PMI, post-mortem interval (hour; defined as the time between death and the beginning of freezing at −80°C); PS, polysubstance abuse; S, suicide; U, undetermined.

^aStorage time refers to the duration between date of the brain tissue being collected for homogenization and the date of death.

^bDrugs that were prescribed in the last month of life.

^cDefined as psychoactive substance use disorder.

^dPrescribed for bursitis, degenerative joint disease, and fibromyalgia.

^ePrescribed for restless leg syndrome.

^fThe duration of illness covers the time between the first display (and not necessarily diagnosis) of symptoms of a depressive illness and the date of death.

^gThis subjects previously met diagnostic criteria for alcohol abuse at 2 and 8 years prior to death.

^hRecurrent MD, in full remission.