Figure 1.
(A) VLCAD−/− mice have significantly lower body weight (P<0.05) than WT mice when fed a high-fat diet ad lib for 100 days. (B) VLCAD−/− mice have significantly lower food intake (P<0.05) as compared to WT mice fed a high-fat diet ad lib for the first two weeks of feeding. (C) VLCAD−/− mice have significantly lower RQ (P<0.001) and (D) lower energy expenditure (P<0.02) as compared to WT controls measured over 24 hours. RQ and energy expenditure measurements were performed on mice pair-fed high-fat diet for 3 months. Both groups n=7. Values are mean ± SEM.