Table 1.

Metabolic profile in plasma of the WT and VLCAD^−/− mice pair-fed high-fat diet for 3 weeks

	WT	VLCAD−/−
Body Weight (g)	28.3 ± 1.4	29.2 ± 0.5
Fat Mass (g)	4.7 ± 0.7	3.0 ± 0.2*
Glucose (mg/dl)	172 ± 7.3	168 ± 7.4
Insulin (pM)	167 ± 33	137 ± 16
Adiponectin (mg/ml)	7.9 ± 0.7	4.9 ± 0.5*
Leptin (ng/ml)	7.1 ± 1.3	3.8 ± 0.5*
IL-6 (pg/ml)	17 ± 3.6	28 ± 4.4
TNFα (pg/ml)	6.8 ± 1.6	9.3 ± 1.1
Resistin (ng/ml)	2.7 ± 0.4	2.1 ± 0.1
Triglyceride (mg/dl)	38 ± 2.5	41 ± 2.5
NEFA (mM)	0.62 ± 0.03	0.81 ± 0.03*
β-Hydroxybutyrate (mM)	0.33 ± 0.07	0.23 ± 0.04
Total Cholesterol (mg/dl)	64 ± 4.9	77 ± 7.6
Fat absorption (%)	99.0 ± 0.3	99.5 ± 0.1
Hypothalamus Acyl-CoA (nmol/g)	48.2 ± 3.8	51.7 ± 6.1

Fat mass and lean mass were obtained from awake mice with a Bruker Mini-spec Analyzer. Plasma glucose and insulin were basal values before the hyperinsulinemic-euglycemic clamp. Data represent mean ± SEM of 9 mice per group.

^*P < 0.01 compared with wild type controls.