Table 5.
Minimally and Fully Adjusted Mean (95% CI) Changes in HDL-C (Δ HDL-C) for Pregnancy and Birth Groups Stratified by ApoE Groups
| Follow-up pregnancy groups: ΔHDL-C (mg/dl) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| P0: 0 pregnancies (referent) (n = 599)a |
P1+: 1+short pregnancies (n = 140) |
B1: 1 birth (n = 222) |
B2+: 2 or more births (n = 186) |
Global p value |
|||||
| ApoE groupb | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | |
| E2 (2/2, 3/2) | |||||||||
| Model 1 (minimally adjusted) |
3.4 | (1.8, 5.0) | −1.1* | (−4.4, 2.2) | −3.8*** | (−6.3, −1.4) | −9.5*** | (−12.4, −6.5) | <0.001 |
| Model 2 (fully adjusted) | 3.2 | (1.6, 4.7) | −1.9** | (−5.1, 1.3) | −3.4*** | (−5.9, −1.0) | −8.3*** | (−11.3, −5.4) | <0.001 |
| Model 2 + waist girth | 2.9 | (1.5, 4.4) | −2.2** | (−5.3, 0.8) | −1.0** | (−3.5, 1.4) | −7.4*** | (−10.2, −4.6) | <0.001 |
| E3 (3/3) | |||||||||
| Model 1 (minimally adjusted) |
1.1 | (0.2, 1.9) | −1.3* | (−3.1, 0.5) | −2.6*** | (−3.8, −1.3) | −3.6*** | (−5.2, −2.0) | <0.001 |
| Model 2 (fully adjusted) | 1.0 | (0.2, 1.8) | −1.5* | (−3.3, 0.3) | −2.4*** | (−3.6, −1.1) | −3.1*** | (−4.7, −1.6) | <0.001 |
| Model 2 + waist girth | 0.7 | (−0.1, 1.4) | −1.8* | (−3.5, 0) | −2.4*** | (−3.6, −1.1) | −2.4*** | (−3.9, −10.8) | <0.001 |
| E4 (3/4, 4/4) | |||||||||
| Model 1 (minimally adjusted) |
−0.6 | (−1.8, 0.6) | −1.1 | (−4.0, 1.8) | −3.5** | (−5.1, −1.9) | −3.5* | (−5.8, −1.3) | 0.015 |
| Model 2 (fully adjusted) | −0.7 | (−1.9, 0.5) | −1.1 | (−4.0, 1.8) | −3.2** | (−4.8, −1.6) | −3.4* | (−5.6, −1.2) | 0.04 |
| Model 2 + waist girth | −0.8 | (−1.9, 0.3) | −0.9 | (−3.7, 1.8) | −2.5 | (−4.1, −0.9) | −2.7 | (−4.9, −0.5) | 0.23 |
n, number at end of follow-up within group (repeated measures analysis includes three follow-up measurements per subject for 94% of subjects in the sample).
Model 1, minimally adjusted means; model includes race, study center, time, baseline characteristics (plasma HDL-C, BMI, waist circumference, smoking status, OC use categories, alcohol intake, physical activity score) and time-dependent age and number of short pregnancies. Model 2, fully adjusted means includes covariates in Model 1 plus time-dependent covariates (smoking, education, months of OC use, and changes in physical activity score and alcohol intake). Model 2 + waist girth; waist girth change added to Model 2 as a mediator of parity-associated HDL-C declines.
Pairwise comparisons of P1+, B1, and B2+ to the referent group (P0): p < 0.05;
p < 0.001;
p < 0.001.