Table 5.
Specific miRNA that play role in normal uterine function and pregnancy
miRNA | Cell type studied | Function | Disease model | Reference |
---|---|---|---|---|
miR-222 | HESF | Decidualization | Normal | (72) |
miR-29c | HESF | Decidualization; Regulates COL7A1, TFAP2C | Normal | (92) |
miR-101a | Implantation sites | Regulates Cox2 | Normal | (97) |
miR-199a | Implantation sites | Regulates Cox2 | Normal | (97) |
miR-21 | Implantation sites with blastocyst | Targets RECK | Normal | (99) |
miR-200 family | Term uterus | Targets ZEB1/ZEB2 through progesterone signaling | Normal parturition; preterm labor | (101) |
miR-338 | Decidual cells | Regulates PLA2G4B | Normal | (102) |
miR-155 | Trophoblast cell lines | Regulates CYR61; regulates trophoblast migration | Preeclampsia | (109) |