Table 9.
Functional miRNA in cervical cancer including precancerous lesions
| miRNA | Cell type studied | Function | Reference |
|---|---|---|---|
| miR-199a | Me-180, SiHa | Proliferation and cisplatinum sensitivity | (159) |
| miR-218 | Cervical cancer cell lines (HPV integrated) | Regulates of LAMB3 | (155) |
| miR-124 | Cervical cancer cell lines | Proliferation and migration | (229) |
| miR-124 | HeLa | Regulates of IGFBP7 | (229) |
| miR-124 | Cervical intraepithelial neoplasia (CIN) | Hypermethylation associated with higher grade lesion | (229) |
| miR-34a | HeLa | Regulates NOTCH1, JAGGED1; cellular invasion | (230) |
| miR-519 | HeLa | Tumorigenesis in nude mice | (231) |
| miR-214 | HeLa | Regulates MEK, JNK1; cellular proliferation | (232) |
| miR-21 | HeLa | Regulates PDCD4; cellular proliferation | (233) |
| miR-143, miR-145, miR-146 | HeLa | Proliferation | (151) |
| miR-122 | HeLa | Proliferation and apoptosis | (234) |
| miR-127, miR-150, miR-185 | HeLa and HuVec | Regulates P2 × 7 | (235) |
| miR-9, miR-200a | Cervical cancer | Important for cancer metastasis | (158) |