Table 4.
Association of midlife vascular risk factor exposure with extensive annual change in MRI markers of brain aging and cognitive performance
Abbreviations: CI=confidence interval; EXT=extensive (see Methods for definition); HTN=hypertension; LM-d=Logical Memory, delayed recall; NP=neuropsychological test battery; OR=odds ratio; SBP=systolic blood pressure; TBV=total brain volume; THV=temporal horn volume; TrB-A=Trail-Making Test B–A; VR-d=delayed recall component of the Visual Reproductions test; WMHV=white matter hyperintensity volume.
Odds ratios (95% confidence interval), comparing the odds of having a raw change of WMHV >1.34 cm3 and of being in the top quartile of annualized change for TBV, THV, LM-d, VR-d, and TrB-A, in participants with vs participants without the corresponding risk factor, adjusted for age, sex, and time interval between the risk factor assessment and the first MRI/NP, as well as time interval between the first and last MRI/NP for EXT-Δ-WMHV, and educational achievement for change in cognitive measures.