Table III.
HRs for incident HCC by metabolic factors assayed at baseline
| Metabolic factors | HCC (n=124) |
Non-cases (n=1018) |
HRa | 95% CI | P for trend | ||
| No. | (%) | No. | (%) | ||||
| Fasting insulin levels, μU/ml | |||||||
| Category cutpoints | 0.0140 | ||||||
| <2.75 | 41 | (33.1) | 354 | (34.8) | 1.57 | (0.96–2.58) | |
| 2.75–4.10 | 16 | (12.9) | 249 | (24.5) | 1 | (Ref) | |
| 4.11–6.10 | 29 | (23.4) | 230 | (22.6) | 1.28 | (0.76–2.15) | |
| >6.10 | 38 | (30.6) | 185 | (18.2) | 2.36 | (1.43–3.90) | |
| Quartile cutpoints | 0.0556 | ||||||
| <2.27 | 32 | (25.8) | 250 | (24.6) | 1.43 | (0.89–2.30) | |
| 2.27–3.60 | 21 | (16.9) | 266 | (26.1) | 1 | (Ref) | |
| 3.61–5.36 | 26 | (21.0) | 263 | (25.8) | 0.95 | (0.58–1.56) | |
| >5.36 | 45 | (36.3) | 239 | (23.5) | 1.78 | (1.15–2.75) | |
| Fasting glucose levels, mg/dl | 0.0161 | ||||||
| <110 | 108 | (87.1) | 955 | (93.8) | 1 | (Ref) | |
| 110–125 | 11 | (8.9) | 43 | (4.2) | 1.40 | (0.80–2.45) | |
| ≥126 | 5 | (4.0) | 20 | (2.0) | 2.37 | (1.12–5.04) | |
| History of diabetes by questionnaire | |||||||
| No | 116 | (93.5) | 995 | (97.7) | 1 | (Ref) | |
| Yes | 8 | (6.5) | 23 | (2.3) | 2.11 | (1.13–3.94) | 0.0192b |
| IR (HOMA-IR) | |||||||
| Category cutpoints | 0.0382 | ||||||
| <0.70 | 48 | (38.7) | 459 | (45.1) | 1.30 | (0.82–2.08) | |
| 0.70–1.02 | 19 | (15.3) | 229 | (22.5) | 1 | (Ref) | |
| 1.03–1.53 | 26 | (21.0) | 190 | (18.7) | 1.20 | (0.73–1.98) | |
| >1.53 | 31 | (25.0) | 140 | (13.8) | 1.97 | (1.20–3.22) | |
| Quartile cutpoints | 0.0175 | ||||||
| <0.46 | 31 | (25.0) | 250 | (24.6) | 1.48 | (0.90–2.44) | |
| 0.46–0.77 | 20 | (16.1) | 270 | (26.5) | 1 | (Ref) | |
| 0.78–1.22 | 23 | (18.5) | 262 | (25.7) | 0.92 | (0.54–1.55) | |
| >1.22 | 50 | (40.3) | 236 | (23.2) | 1.96 | (1.23–3.10) | |
| BMI ≥25 kg/m2 | |||||||
| No | 75 | (60.5) | 716 | (70.3) | 1 | (Ref) | |
| Yes | 49 | (39.5) | 302 | (29.7) | 1.58 | (1.16–2.17) | 0.0041b |
a
HR and 95% CIs were adjusted for number of visits, age (continuous), smoking, alcohol consumption, a first-degree family history of HCC and baseline viral factors, including HBV viral load (continuous), genotype (C versus non-C), HBeAg status and the BCP double mutations.
b
P values were obtained by the Wald test.